O que é osteoporose e por que os ossos ficam frágeis?

A osteoporose enfraquece os ossos e reduz sua resistência. Com isso, fraturas podem ocorrer após quedas ou impactos que antes não causariam lesões.

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O tecido ósseo passa por renovação contínua. Algumas células removem partes antigas, enquanto outras produzem tecido novo para manter o esqueleto.

[{"selector":"#anim-34ccf228-b47f-4dba-894f-58cf098b3912 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-300ad9f9-87a3-4405-b46e-85619b4c27bf","keyframes":{"transform":["translate3d(-115.18988%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-7d4045ea-12c8-46bf-a20c-fd2bae9828f3","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-4cc8af7a-00e9-4722-94ec-cce720515dfe","keyframes":{"transform":["scale(0.15)","scale(1)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"forwards"}] O osso está sempre mudando

A fragilidade surge quando a reabsorção óssea supera a formação por muito tempo. Assim, a quantidade e a qualidade do tecido podem diminuir.

[{"selector":"#anim-e2adf1bb-4dc9-42c7-bf55-31cacb1ff398 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-f1e8c5d8-6a56-40ba-b8bb-d3bc67c03271","keyframes":{"transform":["translate3d(-115.18988%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-5f10527d-d272-4c29-b4cc-ad869091e44b","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-f2cee7f6-900c-45fb-817c-e91f39929432","keyframes":{"transform":["scale(0.15)","scale(1)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"forwards"}] Quando o equilíbrio se perde

Os osteoclastos participam da reabsorção óssea, removendo tecido antigo. Essa etapa é normal e necessária para a renovação do esqueleto.

[{"selector":"#anim-4b82dcce-253a-446a-8763-d6a0baf6b807 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-94ffb8a0-81bc-4f1b-b444-30d7548cea3e","keyframes":{"transform":["translate3d(-115.18988%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-68133708-9cf9-41e3-92b6-525c8297eec7","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-e64b851f-cd43-403e-8800-63a384dc62eb","keyframes":{"transform":["scale(0.15)","scale(1)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"forwards"}] O papel dos osteoclastos

Os osteoblastos produzem tecido ósseo novo. Quando sua atividade não acompanha a reabsorção, a estrutura dos ossos pode perder resistência.

[{"selector":"#anim-ced24d5c-6220-4d7a-ace6-c306ecfbe983 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-6b89f445-7595-41e3-8194-fd96ee3a25bf","keyframes":{"transform":["translate3d(-115.18988%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-29f669e8-7932-4860-9c46-41c9787c98c1","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-6b38e183-8427-423b-b6a3-c41d8669451f","keyframes":{"transform":["scale(0.15)","scale(1)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"forwards"}] E os osteoblastos?

A osteoporose não altera apenas a parte externa do osso. Mudanças na estrutura interna também podem reduzir sua capacidade de suportar forças.

[{"selector":"#anim-cec21023-d7a3-4ba1-a824-8dc32def6671 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-ce12d8f2-0d24-44dc-b76f-0e5d9892a1cf","keyframes":{"transform":["translate3d(-115.18988%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-8a663c8a-f0d9-4e85-a299-899b12ee73ec","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-63dc91bf-82cd-4360-b308-1d45369887c6","keyframes":{"transform":["scale(0.15)","scale(1)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"forwards"}] O interior do osso também muda

Com menos resistência, quedas e outros impactos podem causar fraturas. Coluna, quadril e punho estão entre as regiões frequentemente afetadas.

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A perda óssea pode avançar sem sinais claros. Por isso, algumas pessoas só descobrem a osteoporose após uma avaliação ou uma fratura.

[{"selector":"#anim-de72bde8-cbb3-4986-90a2-b21e8382c054 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-9a2efa44-7afc-4aa7-be50-0ee359f401a0","keyframes":{"transform":["translate3d(-115.18988%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-4645546e-b404-43d0-8ccd-a76f965cfe16","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-afdd21e4-2e3f-41ec-8d87-54c9eeb8702e","keyframes":{"transform":["scale(0.15)","scale(1)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"forwards"}] A doença pode ser silenciosa

Entender a relação entre formação e reabsorção ajuda a compreender como os ossos perdem resistência e por que a osteoporose exige atenção.

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[{"selector":"#anim-1fb4734e-77db-4870-bbe6-67a7938023b3","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-a6544ad3-cdd3-450e-b8cb-eb72cf3b5161","keyframes":{"transform":["translate3d(-122.07206%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-db3a2376-0ce3-4864-8497-b4f7a0d67a11","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-5e65258e-aeee-439c-a8c5-1071fd252b24","keyframes":{"transform":["translate3d(-189.44723%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Veja Mais: Tratamento da osteoporose pode ganhar novo alvo após descoberta em células ósseas