Depressão resistente: cientistas revelam efeito surpreendente da cetamina

SAÚDE Imagem: Gemini Alterações em receptores AMPA podem explicar respostas rápidas ao tratamento

[{"selector":"#anim-dec4eda5-15bd-41af-8024-3c3dc6ad4a31 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-f34cc17a-500a-429c-b14a-295e5701bf03","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-b99145ea-2dcc-4dd0-afb3-f6d4c193d2e9","keyframes":{"transform":["translate3d(-116.38226%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] A depressão maior afeta milhões, causando tristeza intensa, cansaço e perda de interesse diária. Imagem: Canva Pro

[{"selector":"#anim-c842d909-e689-4329-bb38-378f240715b9 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-68ae7ba7-1c9e-4919-a2e9-8de796d300d6","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-4361248e-ab94-4173-89c6-77fbc2747b7a","keyframes":{"transform":["translate3d(-116.38226%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Alguns pacientes não respondem a antidepressivos e psicoterapia, caracterizando depressão resistente. Imagem: Canva Pro

[{"selector":"#anim-ac1de713-e92d-45ac-9c7b-3247b6e7540a [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-94eaeff9-d2ea-49bd-8a88-286292609fe1","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-33c3da19-49d8-4aad-b1c1-0b4e22df28f0","keyframes":{"transform":["translate3d(-116.38226%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Cerca de 30% dos casos de depressão tornam-se resistentes, exigindo alternativas terapêuticas urgentes. Imagem: Canva Pro

[{"selector":"#anim-9cbe9b90-08b0-4e9a-8d17-3cc25e49f025 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-539f6dbe-e98c-4112-8671-115ccdb01a15","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-144ae356-aad0-4521-8c27-a3f30353db2c","keyframes":{"transform":["translate3d(-116.38226%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] A cetamina se destaca, podendo reduzir sintomas em horas ou dias, diferente de antidepressivos comuns. Imagem: Canva Pro

[{"selector":"#anim-2471c19c-30a1-4ded-89e0-7db7cc8a6eb2 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-2f67eaf0-9a76-4ac0-9a56-ddef89a3343a","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-4a6907bd-ddd1-4036-b6d8-9c2f24aa979b","keyframes":{"transform":["translate3d(-116.38226%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Pesquisadores usaram PET (Tomografia por Emissão de Pósitrons) para observar o cérebro em tempo real e entender como a cetamina atua. Imagem: Canva Pro

[{"selector":"#anim-ef7756ac-7583-4d3f-9e79-edffc7621c29 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0.12315240670883233%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-0893cc41-c08c-4b55-a58e-ac4c617a8919","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-dc0ad13a-a202-41b1-9134-6dacf198d8a9","keyframes":{"transform":["translate3d(-116.38226%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] O estudo analisou receptores AMPA, essenciais na comunicação entre neurônios e regulação do humor. Imagem: Canva Pro Estudo cientídico

[{"selector":"#anim-eb61ec22-a7b0-4d16-8b52-42cf5dd6eacf [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-0fcc0c30-bbde-4835-9ff7-82d79b90aec2","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-d4d96cdd-6852-462d-a00f-c9e49ec1dda6","keyframes":{"transform":["translate3d(-116.38226%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Pacientes receberam infusões de cetamina ou placebo, com exames antes e depois do tratamento. Imagem: Canva Pro

[{"selector":"#anim-15859569-c14c-4022-9ac3-6aa29afdee22 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-435a4b9f-a3d3-4e11-8d82-30cfeafb1242","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-8531e9b9-a2f0-43d4-ad52-1ca3563a7be0","keyframes":{"transform":["translate3d(-116.38226%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Após a cetamina, receptores AMPA mudaram em regiões do córtex, habenula e áreas de recompensa. Imagem: Canva Pro

[{"selector":"#anim-7ffafeea-5ad6-478b-be8e-2536a0720e80 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-0366639e-1629-45ea-b2d7-9c733b140a3e","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-91fac52e-96c0-4dda-bbe0-4bcc35193cdb","keyframes":{"transform":["translate3d(-116.38226%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Essas mudanças reorganizam circuitos cerebrais, explicando a rápida melhora de sintomas observada. Imagem: Canva Pro

[{"selector":"#anim-c03d48e5-813c-4b86-932f-86df1b5db494 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0%, 0, 0) translate(25%, 0%) scale(1.5)","translate3d(0%, 0, 0) translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"fill":"forwards"}] [{"selector":"#anim-141aa761-c49f-4390-9c7e-762b808f9f19","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-521bbe13-54bb-425b-81f7-259f31b1c4ff","keyframes":{"transform":["translate3d(-120.13652%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Compreender os receptores AMPA pode guiar terapias personalizadas. Descubra os detalhes do estudo visitando o Fala Ciência! Imagem: Canva Pro Ler artigo